{"id":730,"date":"2010-11-01T17:30:39","date_gmt":"2010-11-01T21:30:39","guid":{"rendered":"http:\/\/www.ptca.org\/voice\/?p=730"},"modified":"2012-11-09T17:32:24","modified_gmt":"2012-11-09T22:32:24","slug":"did-i-cough-say-ace-inhibitors-cough-cough","status":"publish","type":"post","link":"http:\/\/www.ptca.org\/voice\/2010\/11\/01\/did-i-cough-say-ace-inhibitors-cough-cough-730","title":{"rendered":"Did I (Cough!) Say ACE Inhibitors? (Cough! Cough!)"},"content":{"rendered":"

\"VasotecA study in the current issue of The American Journal of Medicine<\/em> confirms what we’ve been telling heart patients on Angioplasty.Org’s Patient Forum<\/a> for a while now: a well-known side effect of ACE inhibitors is a dry cough. The provocatively-titled study is “Angiotensin-Converting Enzyme Inhibitor Associated Cough: Deceptive Information from the Physicians’ Desk Reference<\/a>“.<\/p>\n

It is a provocative article because of the word “deceptive” in the title: the word indicates that patients and physicians are not being adequately informed about the incidence of a side effect of ACE inhibitors: the cough. And is that ever the case!<\/p>\n

The PDR and FDA labeling of the ACE inhibitor enalapril states that coughing has been reported as a side effect approximately 1.3% of the time. So your chances of getting a cough due to this drug are slightly higher than 1 in 100.<\/p>\n

So would you believe it’s more than ten times that: almost 12 in 100? That’s what this study shows. By doing a meta-analysis of 125 studies of ACE inhibitors that constituted 198,130 patients, the authors discovered that:<\/p>\n

The incidence of ACE inhibitor-associated cough and the withdrawal rate (the more objective metric) due to cough is significantly greater in the literature than reported in the PDR\/drug label and is likely to be even greater in the real world when compared with the data from RCTs. There exists a gap between the data available from the literature and that which is presented to the consumers (prescribing physicians and patients).<\/p><\/blockquote>\n

What this means is that when patients find they have this problem (coughing) and they call their doctors, they’re told it might be a side effect of the drug, but that it only happens in 1 out of 100 patients. In reality, this study is saying that it is 1 out of 10: that this side effect of coughing is vastly under-reported.<\/p>\n

Anecdotally, if you search Angioplasty.Org for “ACE inhibitors cough” (hint: select “find all words”) you will see how many patients have posted to our Forum with coughs. By the way, our Patient Forums<\/a> get almost 40,000 pages accesses a month.)<\/p>\n

I understand the patient perspective on this; a number of years ago I was prescribed an ACE inhibitor — and I developed a terrible cough. I had no idea what was going on, until I researched this side effect on “the inter-webs<\/a>“.<\/p>\n","protected":false},"excerpt":{"rendered":"

A study in the current issue of The American Journal of Medicine confirms what we’ve been telling heart patients on Angioplasty.Org’s Patient Forum for a while now: a well-known side effect of ACE inhibitors is a dry cough. The provocatively-titled … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[26,52,59,19,44],"tags":[],"class_list":["post-730","post","type-post","status-publish","format-standard","hentry","category-clinical-trials","category-optimal-medical-therapy","category-patient-alert","category-patient-experience","category-patients"],"yoast_head":"\nDid I (Cough!) Say ACE Inhibitors? (Cough! 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