Study: CT Scans and Stents Successful in Treating Strokes
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L. Nelson
Hopkins, MD |
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January 25,
2009 --
Emergency use of CT scans and stents may be able to treat and
significantly reduce the symptoms of a stroke.
That is the conclusion
of a small study presented this week by Dr. L. Nelson "Nick" Hopkins,
Chairman of Neurosurgery, Professor of Radiology, and Director
of the Toshiba Stroke Research Center at the University at Buffalo,
State University of New York.
The team of researchers, headed
by Dr. Elad Levy, treated 16 stroke patients, as part of a
single center Investigational Device Exemption (IDE) from the
FDA. |
The data, presented at the 21st Annual International
Symposium on Endovascular Therapy (ISET), showed that stents were
able to open
blocked brain arteries in all of the patients, and that
11 patients (69 percent) had significant improvement in their stroke
symptoms.
Dr. Hopkins has been a pioneer
in the treatment of stroke, as well as the non-surgical therapies
developed to treat both stroke and
carotid disease. In an
exclusive interview with Angioplasty.Org,
Dr. Hopkins explains how CT scanning has
been critical to correctly diagnosing a stroke on an emergency basis
and directing the correct therapy.
The correct therapy, in this small patient
sample, included the use of stents to open blocked arteries in the
brain.
Since stents
were first made available in the 1990's, they have been used
to open arteries in the heart, legs, kidneys and neck. They are also
the "gold standard" for the treatment of heart attacks
-- studies have shown that a heart attack being caused by a blocked
coronary
artery can be stopped in its tracks, if angioplasty and/or stenting
is done quickly (90 minutes is the target "window").
Now that same therapy is being applied to
stroke. Current treatments for ischemic
stroke include delivering clot-busting drugs to the blockage
through
the veins or directly into the clot through an artery, or by removing
the clot with a tiny corkscrew-like device or vacuuming it out. But
this early research suggests stents may work better than those treatments.
Dr. Hopkins stated, "Most
patients had significant improvement; for instance, they could
go home rather than having
to be placed in
a nursing home, which is pretty dramatic. Stents
seem to work when clot-busters or other mechanical
devices can't."
Hopkins said that clot-busting drugs only work about half the time because the
blockage can be "sticky" and adhere to the vessel wall, making it difficult to
break up.
Stroke is sometimes referred to as a "brain
attack" because blood flow and oxygen
to
part of the brain is cut off. About 85 percent of strokes are ischemic,
meaning they're caused by a blocked blood vessel. About 700,000 people
suffer an ischemic stroke every year. The remaining 15 percent of
strokes are hemorrhagic and are caused by a broken blood vessel.
The lack of
blood flow and oxygen to the site of the stroke causes the brain
tissue to die. About a quarter of people who suffer a stroke die.
Another
third are severely disabled and may be paralyzed or lose the ability
to speak or remember.
The use of computed
tomography (CT) perfusion scanning has dramatically changed the treatment
of strokes. As Dr. Hopkins told Angioplasty.Org in his interview:
"This has really revolutionized
the way we’re treating acute strokes. The big fear used
to be that we would revascularize an area of the brain that was
already dead and cause a major hemorrhage. If you reperfuse an
area of dead brain, then there is a significant likelihood that
you’re going to have a reperfusion hemorrhage. So these new imaging
studies have helped us to better understand which areas of brain
are in danger versus the areas of the brain that are already
infarcted or dead tissue. The ideal candidate is, if we see a
patient with a major neurologic deficit and we see a large area
of brain at risk without a large area of dead brain. That’s the
kind of patient where we know there is going to be a very major
vessel occluded and we know that we’ve got to get that vessel
open if we’re going to prevent that patient from having a major
stroke. |
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Aquilion™ ONE
320 detector
row CT scanner
(courtesy Toshiba America
Medical Systems) |
Further studies will need to replicate the success of this small
one, but the combination of CT scanning and stent placement to treat
a stroke while it is occurring and prevent the debilitating symptoms
and mortality associated with this event may revolutionize the treatment
of the third-leading cause of death in the United States.
Reported by Burt Cohen, January 25, 2009
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