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Can the level of iodine in the contrast dye used in an angiogram be enough to cause damage to a patient's thyroid gland? What about kidneys?

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Current Postings on This Page (6):

• My 70 Year old father underwent PTCA at a hospital in India. He had 2 blocks. One was found during the angiogram before the PTCA. He was an insulin dependent diabetic for 25 years. Post surgery he had lot of blood loss in the groin area and also went into kidney failure and was put on dialysis for for 3-4 days, apparently due to CIN (contrast induced nephropathy) According to the doctor he also suffered Respiratory acidosis meaning acute respiratory failure and was on ventilator for nearly 6 days. Since he could not eat thru the mouth, he was being fed via a nasal tube. His kidneys became normal eventually. On the 9th day after the surgery, they attempted to wean him off the ventilator. During the time, I suspect some procedures weren't performed by an experienced doctor. He died on the 9th day and the cause of his death is stated as respiratory failure, and cardiac arrest. Anyone experienced similar situations in their treatment of loved ones in hospital care?
Andy, Hyderabad, India, February 14, 2011

• Djacoway -- it's known as contrast-dye nephropathy. Patients with reduced renal function and other clinical situations are more prone to kidney problems when contrast media is used during radiographic procedures. Precautions such as hydrating the patient, using more diluted contrast, etc. are SOP in these cases. What the problem was in your mother's case is hard to say.
Forum Editor, Angioplasty.Org, May 23, 2008

• Can use of the contrast dye cause immediate renal failure? My mother had an angioplasty done approx 2003, with a a coronary stent placed. After approx 4 weeks the stent didn't take, (tissue built up) and the procedure was repeated on this time she ended up with total renal failure--what went wrong, the heart, the kidney or the dye? please help!!!
djacoway, Minneapolis, Minnesota, USA, May 21, 2008

• Since having PCI about a year ago, I also have had a few symptoms of Hypothyroidism, including Bradycardia. I have wondered whether this may have been caused by the contrast dye used during the procedure. Your (Forum Editor) response to the previous post would seem to indicate otherwise. Since reading this post some time ago however, I have read of other persons having similar experiences. Recently I came across this excellent article on Hypothyroidism at http://www.emedicine.com/med/TOPIC1145.HTM I quote from the CAUSES section: "Iodine deficiency or excess: Worldwide Iodine deficiency is the most common cause of hypothyroidism. Excess iodine, as in radiocontrast dyes, amiodarone, health tonics, and seaweed, inhibits iodide organification and thyroid hormone synthesis. Most healthy individuals have a physiologic escape from this effect; however those with abnormal thyroid glands may not. These include patients with autoimmune thyroiditis, surgically treated Graves hyperthyroidism (subtotal thyroidectomy) and prior radioiodine therapy." So maybe there is something in it after all? Cheers.
Keijo Musto, Jamber, April 3, 2008

• Syp -- iodine-containg contrast media is known to be of concern to kidney function -- something that presents difficulty when trying to image renal disease. There are alternative agents that contain less or no iodine -- they may not be opaque enough for the fine detail needed in coronary angiography. We'll call your attention to one European study from 2004, titled "Effect of iodinated contrast media on thyroid function in adults". The study reports thyrotoxicosis (hyperthyroidism) can be caused by iodine in certain patients who have compromised thyroid function, but not hypothyroidism. Can any contrast media experts out there add to this?
Forum Editor, Angioplasty.Org, February 9, 2007

• Can the level of iodine in the contrast dye used in an angiogram be enough to cause damage to a patient's thyroid gland? We are waiting to hear if my husband's blood work indicates that his thyroid is not working properly. He has many of the symptoms of hypothyroidism. He had 2 angiograms within 2 days of each other in July 2005 (one that lasted 5 hours) and had another 2 angiograms in early September. Could all that iodine have damaged his thyroid?
Syp, New Hampshire, USA, January 24, 2007

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