Cordis Celebrates 50 Years of Transforming Cardiovascular Care
A Half Century of Groundbreaking Products, Services and Positive Patient Outcomes
|
|
March 26, 2009 --
As cardiologists are arriving in Orlando for the beginning of this
weekend's 58th Annual Scientific Sessions of the American College
of Cardiology, just a few hours away, Cordis Corporation will be
celebrating its 50th anniversary as a manufacturer of innovative
medical devices. From its humble beginnings in a garage in Miami,
Florida, Cordis has grown into a global organization with well
over half of its $3.1 billion in 2008 sales coming from outside
the U.S. The company’s products now touch an estimated one million
patients every year.
“Our vision at Cordis is to transform cardiovascular care, a field in which incredible progress has been made, but one in which so much more remains to be done,” said Seth Fischer, Worldwide Franchise Chairman, Cordis Corporation. “We
are grateful to the physicians and patients who have placed their
trust in us during the past 50 years. Our legacy of success gives
us confidence in our ability to continue delivering innovative
new solutions that save lives and improve the quality of life for
people around the world.”
“I am so proud of how far Cordis has come over the years,” said William P. Murphy, Jr., M.D., the company founder. “I
look forward to seeing Cordis continue to innovate on behalf
of patients and physicians around the world.”
Humble Origins, Numerous ‘Firsts’
Cordis was founded in 1957 in a garage in Miami, Florida, by Dr. Murphy, the
son of a Nobel laureate. The company, originally named Medical Development
Corporation, rapidly gained recognition as a pioneer in innovative products
for interventional vascular medicine. In 1959, Dr. Murphy changed the company’s
name to the more distinctive Cordis ("of the heart"), indicating its primary
therapeutic focus.
Melvin Judkins,
MD |
|
During the 1960’s, Cordis
became involved in the relatively new field of cardiac pacing
and also introduced the first full
line
of “pre-shaped” Judkins catheters, invented and perfected by
Dr. Melvin Judkins, to simplify catheter insertion by using a
pre-formed catheter into the femoral artery in the groin. This
approach rapidly caught on, virtually replacing the semi-surgical
Sones brachial technique.
Judkins, who practiced at Loma Linda in California, was a
very religious man. He felt that his invention should be used
to further
patient
safety
and
improve
outcomes,
not to make money. So he gave away his patents to a company
he felt would be able to manufacture and provide the medical
profession
with his catheters at a reasonable
price and with high quality. That company was Cordis. |
In the early 1970s, Cordis introduced the first sheath introducers with hemostasis valves, which were designed to minimize blood loss during an angioplasty procedure. By then, Cordis also ranked second only to Medtronic among America's leading pacemaker manufacturers.
In the 1980s, Cordis launched a full line of percutaneous transluminal coronary angioplasty (PTCA) guiding catheters. In the early 1990s, Cordis introduced the first PTCA balloon utilizing nylon balloon material. All of these innovations immediately became industry standards.
Later in the decade, Cordis’s rapid growth attracted the attention of Johnson & Johnson, the world’s most comprehensive health care company, which had its own interventional business called Johnson & Johnson
Intervention Systems (JJIS). In 1996, Cordis merged with JJIS to form Cordis
Corporation, a global manufacturer of cardiac devices, with, at the time, approximately
3,500 employees worldwide.
In 1997, Cordis expanded into the rapidly growing field of electrophysiology through the acquisition of Biosense, Inc., which merged with Webster Laboratories in 1998 to form Biosense Webster.
Today, Biosense Webster is the world’s leading provider of innovative electrophysiology solutions for the treatment of heart rhythm disorders and is responsible for several “firsts” of its own, including the world’s first steerable catheter and ablation catheter, as well as the first mapping system offering electrophysiologists access to 3-D, real-time, color-coded views into the heart’s
electrical activity.
The Stent Revolution
The 1990s
also saw the launch of the company’s biggest breakthrough yet --
coronary
stents. These very small, mesh-metal tubes -- recently named one of the “Top
30
Innovations of the Last 30 Years” by PBS’s Nightly Business Report and the Wharton
Business School -- are used to prop open clogged arteries in the heart once
they
have been cleared of plaque.
In 1994, the PALMAZ-SCHATZ® Balloon-Expandable Stent was approved
by the U.S. Food and Drug Administration (FDA) for coronary
artery applications. |
|
Julio Palmaz,
MD and Richard Schatz, MD |
In 2003, the FDA approved the CYPHER® Sirolimus-eluting Coronary Stent, the first combination drug-device product intended to help reduce restenosis, or “reclogging,” of a treated coronary artery. The American Heart Association named the CYPHER® Stent
one of the top 10 medical advancements of that year.
A variety of clinical studies have demonstrated
the clinical benefits and safety profile of the CYPHER® Stent. For example, SIRIUS, the largest, most comprehensive study ever conducted to evaluate the performance of a new stent, showed that patients treated with the CYPHER® Stent
fared significantly better than patients treated with a bare-metal stent. These
benefits have been shown to be sustained out to six years.
By
early 2006, two million patients worldwide had received the CYPHER® Stent
and, in 2008, the three-million-patient mark was reached, a milestone unmatched
by any other drug-eluting stent at that time.
Cordis NEVO
Stent |
|
The company signaled its commitment
to continue stent innovation with the 2007 acquisition of Conor
Medsystems, LLC, a developer of a unique controlled vascular
drug delivery technology, called Reservoir (RES) Technology.
This technology can be found in the NEVO™ Sirolimus-eluting Coronary
Stent, a completely redesigned stent, incorporating Reservoir
Technology,
an open-cell design, and new bioabsorbable polymer, optimized
to elute sirolimus, the same effective drug used in the CYPHER® Stent.
Cordis recently announced plans to launch a global,
head-to-head, randomized clinical trial called NEVO II which
will compare the NEVO™ Sirolimus-eluting Coronary Stent to the
current market-leading XIENCE V™ Everolimus-eluting Coronary Stent. |
Beyond the Heart
Cardiovascular disease is more than just a disease of the heart. In fact, about
40% of those with cardiovascular disease suffer from peripheral vascular disease,
which is a narrowing of the vessels that carry blood to the brain, legs, arms
and kidneys. Cordis has been a pioneer in this field as well.
The company’s PALMAZ® Balloon-Expandable Stent, for example, was the first stent
to receive FDA approval for use in patients with bile duct obstructions (1990),
for iliac artery use (1991), and for renal artery use (2002). Cordis was also
the first company to introduce in the U.S. a retrievable vena cava filter, which
is used to prevent a blood clot from potentially travelling to the lungs.
Cordis also has been a pioneer in the field of carotid artery stenting (CAS),
a procedure that places a stent in the carotid artery to increase blood flow
in areas blocked by plaque.
Committed to Education
In 2006, the company established the CORDIS® CARDIAC & VASCULAR INSTITUTE(SM) which
provides physicians and other health care providers with educational, clinical,
and product training resources designed to help advance the understanding and
treatment of cardiac and vascular conditions to improve patient outcomes. CCVI
conducts educational programs for thousands of health care practitioners annually
through both live presentation and web-based education programs. CCVI operates
the largest network of cardiovascular procedure simulators in the world for healthcare
provider training with 150 systems in 10 different countries.
Continued Innovation
Cordis’s proud tradition of innovation continues to this day.
In 2008, for example, the CYPHER® SELECT™ Plus Sirolimus-eluting Coronary Stent received CE Mark approval in Europe for the treatment of heart attacks, while a major new study showed that Percutaneous Coronary Intervention (PCI) with the CYPHER® Stent
is comparable to bypass surgery in key safety measures in certain patient sub-groups,
a result that no other stent has demonstrated.
In February of this year, the FDA granted marketing approval to Biosense Webster’s NAVISTAR® THERMOCOOL® Catheter
for the treatment of drug refractory recurrent symptomatic paroxysmal atrial
fibrillation, when used with compatible three-dimensional electroanatomic mapping
systems. AFib, a highly prevalent heart rhythm disorder, is one of the most common
causes of stroke. It is the first and only catheter approved in the U.S. for
this indication.
From its modest beginnings, Cordis Corporation has become a worldwide leader
in the development and manufacture of interventional vascular technology. The
people of Cordis very much look forward to carrying on the company’s long-standing
tradition of delivering innovative solutions that save lives and improve the
quality of life of people suffering from cardiovascular disease.
About Cordis Corporation
For 50 years, Cordis Corporation, a Johnson & Johnson company, has been a recognized
worldwide leader in the development and manufacture of interventional vascular
technology. Through the company's innovation, research and development, Cordis
partners with interventional cardiologists worldwide to treat millions of patients
who suffer from vascular disease.
*Cordis Corporation has entered into an
exclusive worldwide license with Wyeth for the localized delivery
of sirolimus in certain fields of use, including delivery
via vascular stenting. Sirolimus, the active drug released for the stent, is
marketed by Wyeth Pharmaceuticals, a division of Wyeth, under the name Rapamune®.
Rapamune is a trademark of Wyeth Pharmaceuticals.
Source: Cordis Corporation with additional
reporting by Burt Cohen, March 26, 2009
|