Allergic Reactions After Drug Eluting Stent (DES) Hypersensitivity

Current Postings (140) -- Archived Postings on this topic (234):

• Thank you so much for your reply to my enquiry. Just this initial info that you have provided has given me the conviction to pursue the matter further (my Mother had again to visit the emergency Department of the hospital this week after suffering another trembling attack – the Doctor examined her for neurological causes ie a series of reflex tests which proved negative and they are investigating thyroid blood tests). I have contacted my Mother’s heart specialist and asked for details of the stent that has been fitted and have included details of your response which hopefully will provide some justification for exploring the possibility of an allergy. I will advise you of any response I receive. In the meantime I would once again wish to express my gratitude
J.J., United Kingdom, May 9, 2007

• The stent allergy study we are helping with concerns reactions to drug-eluting stents, most likely to the polymer plastic coating. From the description and history you sent in, it sounds like your mother has a known allergy to chrome, or other metals. Chrome dental clasps are actually an alloy of nickel and chrome. Nickel allergies have been well-documented. Most stents are made of surgical stainless steel which contains nickel. The FDA-mandated package inserts for ALL stents, bare metal and drug-eluting, caution against implanting stents in patients with known allergies to these metals. Sounds like the doctors are saying the stent was "plastic-coated". That would indicate a drug-eluting stent. Do you know the name or brand of the stent?
Forum Editor, Angioplasty.Org, May 5, 2008

• My mother, aged 75, has a history of angina and had a stent fitted on 9th June 2007, at Sandwell District Hospital. Since then she has spasmodically not been feeling well – her symptoms include sickness, headaches, trembling. The most recent of these “turns” has been today – she went to the hospital and had a full check on her heart including an ECG, blood pressure etc. The doctors assured her that her heart was fine. I have today started to research the possibility of an allergic reaction to the stent – we have on numerous occasions raised this with the Doctors but they have dismissed our theory. They say it is nerves, or rheumatism or age etc. The reason why we think it could be an allergic reaction is that my Mother’s symptoms are very similar to what she suffered some 15-20 years ago – it transpired that she had a reaction to a denture clasp fitting which turned out to be chrome – when this was eventually removed she recovered rapidly. Until that point she had suffered a general feeling of being unwell and unable to participate in activities etc. The doctors have said that the stent they have fitted is not metal but plastic coated – to what extent they are certain of this I do not know – but given that my Mother is susceptible to allergic reactions and I have discovered that some people do suffer even when it is plastic coated I feel it is worth pursuing this line of enquiry. Especially given the impact of the general feeling of constantly being ill is having on my Mother’s general well being and making her so depressed given that normally she is an exceeding young and active 75 year old. I would very much welcome any information/advice that you can provide. Many thanks.
J.J., United Kingdom, May 2, 2007

• Deborah and Niloofar -- as we've noted before, very little is known about hypersensitivity reactions to drug-eluting stents -- and one of the confounding issues is that patients with stents are also patients who take a number of different medications, each of which has its own set of adverse or allergic reactions. Also, because these reactions are small in percentage, it is very difficult (and expensive) to run large enough studies that will yield valid data. Two cardiology groups in Texas and Chicago are studying this (see "To Patients" notice in the right column). What they do is remove each medication (substituting a different one) to rule out drug reactions, and then do a skin patch test with small pieces of the various stents. If the skin reaction is positive, there is a high likelihood of allergy to some part of the stent (it is thought that the polymer-coating is the culprit). One option is to visit an allergist to see if a drug you are taking might be the cause. As for a fever and rash two years after stent implantation, probably unlikely -- and certain antibiotics are known to cause rashes in some people.
Forum Editor, Angioplasty.Org, May 2, 2008

• I have a problem that I haven't read here. I had 2 medicated stents inserted in Feb of 05. 10-12 days later I had several canker sores in my mouth. At the time I was 53 Years old. Before then I may have had 2 or 3 in my entire life. Ever since then I've repeatedly had 1 or up to 3 in my mouth. After it heals I get another. I am seldom without them. Is this some kind of reaction to the stent (or Plavix) or did I pick up something in hospital. Help!!
Deborah, Alabama, USA, April 26, 2008

• Greetings, My Dad is 82 years old and had two DES put in his heart, two years ago. Few weeks ago he caught the flu and a week after he was recovered, he had high fever for 24 hours and was put back on antibiotics, which led to having rashes. Could the rash and fever be a reaction due to the DES? I appreciate any feedback. P.S.: he is taking plavix, metoprolol, lipitor, flomax, Nexium.
Niloofar Yekani, Connecticut, USA, April 15, 2008

• Debbie and Sue -- we have sent you information about the stent hypersensitivity study being conducted in Texas and Chicago. if you browse around this toipic, you'll see a range of unexplained symptoms that patients have reported to us, symptoms that started after a stent was implanted. There are 4 possibilities:

Many patients report that their physicians believe this last explanation is the most likely, But given the number of postings here and the similarity in symptoms, we disagree and think that the last explanation is the least likely. Drug and metal reactions can be tested for by an allergist. If they don't exist then a possible explanation is a reaction to the drug-eluting stent. The study being done by the Texas and Chicago hospital does exactly this -- they eliminate other causes step-by-step and then administer a skin patch test, using a small part of an actual stent. They report to us that they are definitely seeing a correlation between positive patch tests, symptoms and inflammation at the stent site. The reason most doctors are unaware of this possibility is that there have been no studies published on the topic. The study we are involved in is the ONLY one of its kind, to our knowledge.
Forum Editor, Angioplasty.Org, April 11, 2008

• My mom had a Cordis stent put in in January 08. Immediately after she started to complain of intense pain in shoulders & arms & wrists. Her hands went numb & were so pained she would go days without sleep. Shortly after that both her knees blew up & were very painful. She is not able to get up from a sitting position. she is on Plavix. She was diagnosed with carpel tunnel in both hands & had surgery on one so far. The pain has subsided in that hand but not the tingling & numbness. Her cardiologist insists this is not relayed to the stent or the plavix. i am finding it harder & harder to believe. can you please furnish me with as much information as you can on side effects of medicated stents & plavix. i forgot to mention she took Vytorin for a month after surgery as well. My mom's health was great before this stent. I suspect she is rejecting it. Any help would be appreciated. Thank you
Sue, Florida, USA, April 5, 2008

• My mother had two stents placed in her heart in January 2008. She has had severe nausea EVERY DAY since then. She had congestive heart failure but never had any stomach problems before. The doctors have done many many tests and have given her every kind of medication. She is now on the medication given to chemo patients for nausea and she sleeps all the time or is very sluggish when awake. Her quality of life is GONE. We were not told of any side effects at all before the stents were put in. The doctors are very indifferent about this problem and act as if it is a total mystery to them and they have never heard of this reaction!! Please let us know what can be done!!!!!!!!!!!
Debbie N., Indiana, State, USA, March 30, 2007

• Brian -- hard to say, which is why we're sending you information about the drug-eluting stent study being done in Texas. One of the protocols is to take patients off of each drug (using an appropriate substitute) and once that's been done and the symptoms remain, they use a skin test to see if there might be a reaction to the drug-eluting stent material (not so much the metal, but the polymer/drug combo). Read our article "Drug-Eluting Stents May Cause Allergic Reactions" about a study published two years ago -- this is still a little-understood syndrome and, as newer drug-eluting stents come on the market, may change. Hope this helps.
Forum Editor, Angioplasty.Org, February 3, 2008

• I am a 45 year old male. On Dec 26, 2007 had one Taxus Express 2 drug-elating stent placed in the circumflex (which was 80% they also say I had a 100% that fixed itself). Upon discharge, I was placed on Plavix 75 mg., Metoprolol Succinate ER 25 mg., Lipitor 80 mg., Altace 2.5 mg., Ecotrin 325 mg.. all once a day. (prior to stent placement only meds I was taking was Lipitor 20 mg and Ecotrin 81 mg Once a day) Had no hypertension issues and cholesterol on Lipitor was about 140 (good cholesterol was a little low)

I informed the Cardiologist I was against such a raise in the Lipitor (from 20-80) he stated it was just for 2 weeks, well after 2 days I could feel the pains in the lower back and the legs, I called him and immediately put myself back down to 20mg. This was on 12/29/07.

Went back to work as Bus Operator on 1/10/08, everything was fine until 1/21/08, At the end of my shift, My arms, elbows, wrists, hands, fingers, knees, and ankles were very painfully swollen and sore. I had to go the the emergency room, they drew blood and told me it was probably an allergic reaction from the Altace (ACE inhibitor). The E.R. gave me an I.V. with Benadryl, Steroid and pain killer, went home 3 hrs later feeling fine. Stopped taking everything except Plavix and Ecotrin on 1/22/08. Stayed home until 1/25/08 went back to work and at the end of my shift, the same thing happened with all the same muscles and joints swollen and painful. Saw the Cardiologist on 1/28/07 he placed me back on the Metoprolol and lowered the Ecotrin to 160 mg. While still badly swollen, I saw my PCP on 1/30/08. He also agreed that this more than likely is a reaction from the ACE inhibitor He placed me on Prednisone 20mg and Benadryl 25mg once a day and return to Lipitor 20 mg. and lowered the Ecotrin to 81 mg.. This seemed to clear everything up. So I went back to work on 1/31/08 with the same results, at the end of my shift at night all the same muscles and joints became swollen and painful. I went back to my PCP and he raised the Prednisone to 60 mg. for 2 days than 40 mg for 2 days than 20 mg for 6 days. He also suggested that I change the Metoprolol to Coreg CR. I'm going to take the next 7 days off to rest the muscles and joints than try to go back to work.

I've been doing a lot of internet surfing in my free time at home, nobody seems to be definitely positive that it is the ACE inhibitor, The E.R. said it could take a couple of weeks for the ACE inhibitor to clear out, is this true?.I'm afraid it might not be. Could it be the DES or one of the other drugs (never had any problems with Lipitor) I been pretty healthy and active all of my life, playing racquetball once a week, mowing the lawn, swimming etc.. I'm new at this and quite concerned about what my next step should be if this problem persists. Help!!
Brian G., New York, USA, February 2, 2008

• A. Gregory -- aches and joint pains are a known side-effect of statins. You should discuss this with your cardiologist -- perhaps other methods of lowering cholesterol can be an adjunct.. Let us know what he/she recommends.
Forum Editor, Angioplasty.Org, February 2, 2008

• I have been taking Plavix, Hyazaar, Herbessor,Vasteral and Lipitor. I am a 58 year old female. I get a lot of aches and pains almost everyday but I need to get my Cholesterol down so I continue with taking Lipitor. Lovastatin also does the same thing but it does not lower the Cholesterol. In the long run is it harmful if I carry on with the Lipitor?
A.Gregory, Malaysia, January 29, 2008

• R.G. -- we can't give any specific medical advice, but you're definitely doing the right thing by meeting with your cardiologist about your drug regimen. Sounds like the statins might have been causing problems, but again -- this is something only your doctor should advise you on -- not us, or any internet site! We've definitely heard a lot from people with nickel allergies -- we've not found any medical literature definitively stating that this can cause serious reactions, but the cautions DO exist in the "Instructions for Use (IFU)" mandated by the FDA, so there must be some evidence.
Forum Editor, Angioplasty.Org, January 29, 2008

• My list of medications include two statins atenolol, cozaar, Lasix, another blood pressure medication and 2 medications for acid reflux. I have just recently stopped the statins. The docs adjusted the statins down to an every other day administration. But I have felt so much better on the days that are absent the statin that I have taken an occasional extra day off of the med. This last weekend I decided not to take the statins (Zetia and Pravachol) and am able to get out of bed and have noticed less pain. I will be addressing this change with my physician. I was not asked about anything but medication or food allergies. I remember because on a later hospitalization I added nickel to my list. Statins are on the list. What are options for my predicament?
R.G., Wisconsin, USA, January 29, 2008

• Valerie -- stents cannot be "removed" once placed. But drug-sensitivity to Plavix is a known problem (rash, etc.). Read over our Forum Topic on Plavix and Stents. There is information there that may sound familiar. As for dealing with this situation, several groups have published papers on desensitizing allergic reactions to Plavix -- one in Iowa and also at Scripps in La Jolla. We'll soon be posting an exclusive interview with Dr. Karl von Tiehl of Scripps, lead author on a paper published in the November 5 issue of the Journal of the American College of Cardiology, titled "Clopidogrel Desensitization After Drug-Eluting Stent Placement". In this paper, which you might want to show to your cardiologist, Dr. von Tiehl describes the protocol for desensitization which, he tells us, is one which any qualified immunologist familiar with the area of drug desensitization should be able to carry out. If you or your doctor have further questions, feel free to post here, or even call Scripps. Good luck and let us know how you fare.
Forum Editor, Angioplasty.Org, January 29, 2008

• My dad (75, quadruple bypass 5 years ago) had angioplasty 3 weeks ago and had one DES put in for a significant blockage in 1 artery. He was put on Plavix but seemed to have an allergic reaction (itchy rash on chest) and was then put on Ticlid He's now experiencing a worse itchy rash. His cardiologist had said before there was no alternative to taking one of these 2 drugs for at least 5 months, that Coumadin and aspirin wouldn't work for this. How can we find out for sure if he's allergic to these medicines, or something in the stent itself, or maybe even the dye used in the angiogram? And if he is allergic to both medicines, what can be done? Remove the stent and put in a bare metal one? Another bypass?
Valerie M., New York, USA, January 29, 2008

• R.G. -- yes, pretty much all stents (drug-eluting AND bare metal) contain nickel and the FDA package insert / instructions for these clearly state that the device should not be used (or used with caution) in patients with known hypersensitivity to any componet of the stent. The tricky part here is the "known hypersensitivity" (a.k.a. "allergy") -- patients are supposed to be asked about allergies, etc. but we've found that many patients report not having been queried about this -- or they don't realize how important this information can be. It's also not clear as to how severe such a metal allergy can be (the stent is quite small). Are you taking other meds? For example, joint pain is a known side-effect of statins. But definitely see your cardiologist about your reactions -- he/she should be able to offer you some information and help. Let us know what you find out.
Forum Editor, Angioplasty.Org, January 20, 2008

• I wonder if I am allergic to Plavix? My symptoms include stomach upset, shortness of breath, severe pain in ankles and wrists. I am lactose intolerant and I have read that Plavix tablets contain lactose. I am allergic to nickel and I have read that taxus stents contain nickel. I would like to know if this is true and how should I approach the possibility of allergic reaction with my cardiologist or my family physician. I have had 4 stents placed in my RCA and D1 and continue to be semi bed ridden. What do you suggest?
R. G., Wisconsin, USA, January 18, 2008

• I am a 56 year old female that has recently (Nov.2007) had a Taxus Drug Eluting stent put in my LAD artery that was 99.9% blocked. I also had an angioplasty done on a smaller artery at the same time. I was involved in a car accident on Aug.11th, 2007, no fault of my own, this accident caused a major back problem that I was scheduled to have surgery on Nov.29th 2007. I began having chest pains, some worse than others, that concerned me enough to see my family Dr. He did an ekg, showed a problem, had a stress test which also showed a problem. My Dr. sent me to see a cardiologist in Joplin Missouri.He did an echo-cardiogram and found the problems. He never told me that my condition was life threatening, but he did tell my husband that the front part of my heart was barely getting any blood or oxygen to it. Had my heart work done on Nov.26th, 2007. the first thing I noticed immediately, was that my breathing was sooo much better!!! I felt wonderful until 4-5 days after my procedure. Then, all hell broke loose. I developed a itchy red rash like I have never experienced before! I still have scars where I scratched so hard. My Dr. gave my a 6 day series of a steroid pill which got rid of it. I guess I'll never know the cause of the rash, I thought it might have been the white contrast dye that was used to find the blockages. Since then, I have never felt better. My cardiologist was a gift sent from God, as I was so close to having a heart attack. Ironic, how an auto accident actually saved my life. I think the stress of the wreck is what started these angina pains, the pains are what made me get checked out. I feel like the Taxus stent has given me a 2nd chance at life. I feel great!!! Thank you, thank you, thank you to Dr. Robert Stauffer, Freeman Heart Institute Joplin Missouri.......
Norma Wilkes, Afton, Oklahoma, USA, January 14, 2008

• My name is Ken and I posted on this site in Oct/Nov of2006. In Aug 2006, I was given a cypher stent. I had 3 previous bare metal stents with no problem. I had refused the cypher stent, declined it in writing in 2004 when it was brand new, as I have a severe allergy to all Mycin drugs and their derivatives, This was clearly noted on my charts and records at the hospital and with my Dr. also on my allergy wrist band. 1 week after implant of stent I was readmitted with severe pain and blood pressure at 240/127. Re-catheterization showed the stent was still in place but during procedure I went into full arrest. Did I mention that I also have a pacemaker from 2005. I survived and wished that I had not. I lived with severe pain for several months and slowly regained some signs of life as the drug wore off. Problem came back in august 2007, and my NEW TEAM of specialists, did not feel that the stent was the problem. Back into cath lab and two more stents BMW were placed in to relieve recurring pain and weakness in left side. November I began to fail badly. BP out of control with any medications, back into hospital emergency room late november. Diagnosis was restenosis 95% or more in the medicated stent. Also showing some muscle damage to heart. Overworking? Bottom line on Monday 1/14/08 I will be back in again for bypass surgery to the blocked gx--ffd cypher stent. Never, Never Never risk a medicated stent. Be aware that Drs make more money using them and there is no way that I will ever believe that my first Dr was acting in my best interest. When I said no medicated stents I thought it meant forever. His lawyers argue no. With my other problems, I will survive this ordeal ONLY BY THE GRACE OF GOD... I TRUST IN HIM and No-one else. I did report this to the texas team doing the study and heard nothing. I wonder who is paying their bills. My bills for health last year $175,000.00 20% out of pocket.
Ken Feeley, Bonita Springs, Florida, USA, January 12, 2008

• Jackie -- the red rash is often a sign of allergy to a drug, usually Plavix -- but your aunt should NOT stop taking Plavix -- it's critical after stenting to stay on antiplatelet therapy to avoid clotting. One question: did your aunt begin any new drugs at the same time as the stent placement? These might be one cause, but she should certainly see her interventional cardiologist and discuss these symptoms with him/her. You might also email us at the address in the sidebar (under the "DONATE" button) to get some information on the stent allergy study being conducted in Texas.
Forum Editor, Angioplasty.Org, January 11, 2008

• I have an Aunt in Arkansas and she had drug eluting stents (6 months ago). She started the day she had them with vomiting, then she began to break out all over her body with a red rash and itching. She has been to all kinds of doctors and has continually gone down hill. She is very weak, has very low blood pressure. She was doing well until the stents were placed in her. She now has begun to have kidney and bowel problems. Do you know if she needs to go to an allergy doctor to find out if she is allergic to the stents or the medication in the stents?
Jackie, Millington, Tennessee, USA, January 8, 2008

• Plavix and Aspirin Resistance is another Issue. If the Plavix fed bleeding Ulcer don't kill ya then your dual antiplatelet the rapists oops (therapy) aint workin because as many a 1/3rd tested on such may be resistant to Plavix and aspirin see Accumetrics VerifyNow to get tested, Then ask your doc why he didnt test before.
stent clots x 3 and counting , realist, Florida, USA, January 7, 2008

• On Sept.19, 2007 I had two DES placed in my RCA and D1. One is extra long. I was told that I had two 80% blockages. Afterwards I experienced some slight pressure in my chest and an ache in my right arm which have worsened as of this date. I am short of breath while doing the most simple thing. I have an allergy to nickel but was not informed that DES have nickel in them. The cardiologist thinks that I am just sensitive to the stents. But I am sick and very tired. Walking on a treadmill for 20 minutes is my limit. I cannot motivate myself to exercise. Any suggestions would be appreciated.
Rachel G., Wisconsin USA, December 28, 2007

• Does anyone have any ideas as to how to become desensitized to the des stents themselves, 6 allergy pills are not quite enough even while watching my diet very carefully? Denise Pgh PA again
Denise Knoche, unfortunate recipient of 2 des stents in RCA, Pittsburgh, Pennsylvania, USA, December 26, 2007

• I have a Boston Scientific Taxus stent and a regular stent. I had the regular metal stent for 5-years. I've had the DES since Feb 2006. I have experienced a higher CPK-level 199 and SEDRATE 32 (associated with inflammation). I have swollen features associated with inflammation. I have been put on a water pill to reduce swelling and it hasn't helped. I was on Vytorin (statin) for awhile longer than the DES. I have experienced muscle soreness and weakness. I used to run 2 miles at 3.6 mph. No longer can I even walk without my left leg dragging due to weakness after 10-mins. I am right-handed and my right-arm is so pained that I cannot reach across my body to wash the left-side of my body. My muscles are so weak and pained that I cannot sleep through the night w/o tossing and turning due to my body touching a surface. NOTE: I bought new mattresses about 1-year ago because I thought my back pain and body soreness was due to my mattresses - it was not. I went to a neurosurgeon for back surgery who indicated that I was not hurting where I should have been hurting for the back misalignment which was analyzed in an MRI. So, he sent me to a Physical Therapist. On day one with the PT, she indicated that my pain was muscle since she could not move my legs without my screaming in agony. I was taken off of Vytorin (statin). I am feeling a little better but the inflammation and pain persists. My CPK and sedrate is still high. My neurosurgeon has referred me to a neurologist.
Cynthia, Indianapolis, Indiana, USA, December 13, 2007

• Four weeks after having a coated stent installed in 2005 I started to have severe joint pain in my hands and feet. I still have this today and I have had MRI's to examine the joints and there was no Arthritis. I had no history of joint pain before this time and I would like to know if anyone else has experienced this problem.
Ken A., Pennsylvania, USA, December 11, 2007

• Sharon -- you wrote in about a "stainless steel/nickel implant" -- are you talking about a stent? Or something else. We haven't heard anything about fungus infections from stents. Does anyone out there have any info on this?
Forum Editor, Angioplasty.Org, November 29, 2007

• I had a stainless steel/nickel implant and I developed a fungus infection from it. Mold releases mycotoxins which are a neurotoxins. It is a multi-symptom, multi-system disease. I am sick as a dog and am going through detox but getting better. Mold exposure is a biotoxin disease. Why in the name of good medicine did it take me five years to figure this out. Why did the doctors not look for a fungus infection. Fungus infections have been around for millions of years why would the medical profession not look for this?
Sharon, Denver, Colorado, USA, November 28, 2007

• Martha -- thanks for the quick response. It seems that it would have been better if the nurse-practitioner had talked to you PRIOR to your procedure. This is something that we at Angioplasty.Org have been writing about and campaigning for since more than a year ago. It's something we testified to the FDA about. Patient AND physicians need more education about drug-eluting stents and the need for long-term Plavix. Not just whether drug-eluting stents are as safe as bare metal stents -- the important issue we see is exactly what you've experienced. Physicians need to be aware of the implications of implanting a device in someone -- a device that requires the patient to stay compliant with dual antiplatelet therapy (Plavix and aspirin) long-term, for a year, two, maybe for life. And they need to communicate these implications to patients BEFORE stent implantation. Some patients cannot be compliant for financial reasons (see our topic on Financial Assistance for Plavix for some unfortunately good examples); others cannot be compliant because of allergies or clinical conditions such as yours; others may need to have surgery in the near future, and Plavix often needs to be stopped for that. All these issues need to be weighed against the higher incidence of restenosis with bare-metal stents -- but it's a decision that should include the patient!
Forum Editor, Angioplasty.Org, November 24, 2007

• You asked why the nurse practitioner said I should have not had a medicated stent. She presented me with the facts about taking Plavix and said I would not have had to take it as long, 3 months only with a bare metal stent. My history of reactions to meds. is several medications with two hospitalizations. She changed me to Ticlid for a while after this pain and weakness in arms started but it didn't change anything so I was told to go back on Plavix. I thought it was more heart problems but went in for an Echo and the Cardiologist said it was not my heart but a flare of my arthritis. My Rheumatologist put me on 20 mg. Prednisone daily and I usually respond quickly with that but so far none. It has been 3 mo. since my stent placement.
Martha M., Missouri, USA, November 24, 2007

• Martha -- can you tell us precisely why the nurse-practitioner said you shouldn't have gotten a DES? We know that Ticlid can cause liver problems, so it's not recommended. Reduced liver function also brings up a "use with caution" for Plavix, but it's not an absolute contraindication. We're assuming the nurse is concerned that you'll need to be on Plavix for a year, whereas with a bare metal stent, it would only be 6 weeks. What has the interventional cardiologist said about this situation? He/she may have had a good reason for the medicated, or drug-eluting stent (DES) but what is the explanation for why you're not feeling well? There is a study going on out of Texas which you can get more information about in the right hand column.
Forum Editor, Angioplasty.Org, November 24, 2007

• I recently had a medicated stent (that was all the Dr. told me) I am not sure which kind. I also have a liver disease called Primary Sclerosing Cholangitis, caused by the type of arthritis I have. After I had surgery the Nurse Practitioner came in and said "you shouldn't have had a medicated stent" did you not tell your Dr., I said "no but it was on my chart", she said don't ever depend on the Dr. reading your chart. Two weeks after having my stent placed I started having very severe arm & shoulder pain, called and made an appt. with the cardiologist, he said nothing wrong with your heart and sent me to my Rheumatologist, she gave me a Prednisone shot and 20 mg. Prednisone daily. My response has not been good, usually when I have increased inflammation it will get better quickly with Prednisone. I was changed to Ticlid from Plavix which did not do any good, now back on Plavix. I am desperate for help, I feel so much worse than I did before the stent. I truly feel that I am allergic to it. Had I known the facts and been asked which stent I preferred I would have said "bare metal". However I am just a patient, since I have lived with this body for 74 years I know there is something else wrong. I can't comb my hair or put dishes in my cabinet because my arms and shoulders are so weak and painful.
Martha M., Missouri, USA, November 23, 2007

• I am a 43 year old Australian woman who had three cypher stents following an arterial dissection in my LAD. Like Ken R from Georgia, I have had dull chest pain and tingling in my left arm since my heart attack. It, too, lessens with exercise and drives me crazy some days like a tooth ache. My doctors seem to think it's psychological. If anyone can shed some light on this problem, I'd appreciate it. I don't think it can be related to the stents as it was there post heart attack and prior to any treatment at all.
Michele Medway, Gunning, New South Wales, Australia, November 22, 2007

• I'm a 36yr male Correctional Officer, Pos PPD,latent TB 2004 Had a reaction to INH (chemotherapy medication)caused Neuropathy in tongue(burnt taste),fingertips toes,sides of legs,tinnitus,extreme fatigue,memory loss, gallbladder disease(gallbladder removed june2005), B-12 Deficiency discovered right before gal bladder removed started b-12 shots in july...they helped a lot LAD stent(Taxus express2) put in on 11/14/07 I told the ER I was allergic to INH...I guess they couldn't put 2&2 together..I felt fine for 1 day after surgery and have started feeling the same pain that I was experiencing before surgery....I just found out that the coating on these stents are (chemotherapy medicated) Hello! I am reading all of these stories just looking forward to what Ill have to endure...the good news is I already have tinnitus,tiredness,neuraphthy....Now I get to look forward to a rash it looks like...sorry for sounding so neg..just sick of being sick!..My suggestions for persons who have received one of these stints is to get a blood count on your B Vitamins specifically the b-12 I do not think there is a way to repair the nerve damage after you lack the B-12 another is to stop using Proton Pump Inhibitors(protonix, prevacid, nexium, even zantac)-they cause me to have severe explosive diarrhea, pepcid seems to be ok...or just good old mylanta or tums! The pump Inhibitors does not allow your enzymes break down the Vitamin in your food and the chemotherapeutic drug coating is killing the enzymes or better known as intrinsic factor. So there is a double whammy accuring...another safe bet would be to use the b-12 pills that you can place under your tongue. That way you can get the B-12 straight to your blood bypassing your stomach and feeding the nerves that are in danger of not getting the b-12 they need to function! Also more good news I believe the medication in the stent only last for about a year so after that hopefully the inflammation around that area will go away, till then as I have learned in the past Grin! and Bear it! The alternative would be nonexistance...and that would hurt everyone that loves you!
Aaron Smith, Cumberland, Maryland, USA, November 18, 2007

• Sharon -- we have sent you information about the cardiologists who are conducting this study (also being done in Texas). Allergic or sensitivity reactions are often difficult to diagnose so we hope this can be of some benefit. As for the stent being replaced, that can't be done -- sounds like the stent began to restenose (tissue was growing inside of it) and usually in these cases, either a balloon is used to open up the stent, or another stent is placed inside the original. Keep us informed as to what, if anything, you find out -- and good luck.
Forum Editor, Angioplasty.Org, November 18, 2007

• I am very much interested in the stent allergy study. I had a Taxus Express 2 Paclitaxel-Eluting Coronary Stent March 2, 2006. By the end of May I was having trouble breathing again and retaining fluid. By December 2006 I was having bad breathing problems so they went back in the end of Dec 2006 and the right coronary artery which they had placed the stent previously that year was grown over and blocked with some kind of matter (doctors words) that they had to remove. The doctor said if I continued to have a problem with it they would take the stent out and replace it with another one. Since that happened I have had strange things happen to me that the doctors haven't been able to explain. My face, neck, arms and legs turn really red which is worse at times than at other times but pretty much stays there. My throat and mouth broke out with blisters and was really red. I don't break out with blisters now but my throat, mouth and tongue all get really red and hurt. My throat actually closed up on me and I had to go to the ER. It had been sore for a couple of weeks and then I couldn't breathe one morning. Everything in my mouth and throat was swollen. They did a CAT scan and said everything was red and swollen all the way into my chest. NO Fever. My uvula, my epiliglottis etc.... all red and swollen. That was Oct 11, 2007 and I am still on steroids and my throat is still red, It is worse then better etc.... I have nasal congestion too. I have been to a immunologist/allergist, ear nose and throat, rheumatologist doctors and fixing to go to an infectious disease specialist. Thus far everyone is clueless as to what is going on. I also bruise really bad, have extreme fatigue at times and am hoarse. Not sure where to go from here but was hoping that this could be the answer. Please respond if you think it is possible that the Taxus Stent may be the culprit. I hope I have remembered everything.
Sharon G., Texas, USA, November 18, 2007

• Denise -- hopefully the group of Texas cardiologists can help you. As for your developed sensitivity to Plavix, we just conducted an interview with Dr. von Tiehl of the Scripps Clinic in San Diego. He is the lead author of a study published in this week's Journal of the American College of Cardiology, titled "Clopidogrel Desensitization After Drug-Eluting Stent Placement". They've had great success with this and he recommended that patients consult an allergist who is capable of delivering drug desensitization therapy (probably one at a large university center) and he/she can reference Dr. von Tiehl's article for details.
Forum Editor, Angioplasty.Org, November 18, 2007

• Nov. 13, 2007: After 2 Taxus des stents, without pre surgery consult as to choices in stent world, were implanted March 2006, I experienced a hypersensitive reaction to same. This created a domino effect creating many more allergic reactions over the next 18 months. I even became allergic to PLAVIX after 9 months, so now what am I supposed to do!!! I am not able to follow the lifelong duel antiplatelet therapy that is supposed to protect me from clots? I have also developed allergic reactions to SOY, MSG, NUTS, RAW FRUITS AND SOME RAW VEGETABLES, AS WELL AS ANYTHING CURED, AGED OR FERMENTED AND MY RAGWEED ISSUES ARE OVER THE TOP! Does anyone have any advise, I have enrolled in the study out of Texas. Is my risk for clot increased because of my hypersensitive reaction??? The reaction I have experienced is softball sized hives, malaise,and fever for approx. 3 days. I have seen an allergist and take Fexofendine,4 Cimetidine and Hydroxyz HCl daily. This prevents hives only until a new allergy develops, and I must eliminate yet another food from my diet. Would anyone like to guess if this is temporary or permanent?????
Denise Knoche, patient given no stent choices prior to surgery, Pittsburgh, Pennsylvania, USA, November 13, 2007

• I think I have an allergy to the nickel in my stent. What can I do?
William Lipoff, Plantation, Florida, USA, November 8, 2007

• Every since I've had my Cypher stents I have been living in pain and lost my ambition. I have pain in the muscles of my arms and legs, pain in my joints, and a very annoying pain in my back between my shoulder blades. I told my primary care doctor and he took me off the statin drugs that he put me on. It's been over 6 months and I have been living on motrin and getting more annoyed with the doctor who looks at me like I am crazy when I go to see him with the same story. Is there any help for me?
Elizabeth W., Roseville, Michigan, USA, October 24, 2007

• Update to May 6, 2007 posting for William Blanton regarding cypher drug eluting stent. We finally heard from the University of Texas-they don't think the inflammation found in Bill's mouth is related to the stent but don't know what to make of it. This week Bill was to his heart doctor and his doctor finally told him it is a reaction to the stent. They don't know what to do since you cannot stay on prednisone for any length of time. He said at least you are not dying just suffering. I am not sure what that exactly means. They won't risk taking the stent out unless he gets in the position he is dying from it and it is the only hope. They might attempt it then. They said the stent is affecting his immune system that is why he has skin problems, allergies, sore throat, severe mouth and tongue pain. It is causing the inflammation in the mouth. They cannot give a prognosis since they do not know that much about this. His condition is chronic and he will have to live with it however long that is. The only real hope for the future is possibly a new drug that might help relieve some of the symptoms. We are not there yet. We have given up on any good out come with this. On the issue of fatty tumors- Bill had one on his arm before he received the stent-he now has two. Someone on the forum asked about this-don't really know what this says either. Once again thanks for listening and I hope all of you on this forum find a answer and some help. My heart goes out to all of you and thanks to the forum for making this insight available to all of us. If anything changes or we get anymore information I will let the forum know. Thanks again.
Terrie Blanton, Hamilton, Ohio, USA, October 19, 2007

• I am experiencing the same symptoms: Dull, chronic chest pain, tiredness, etc. along with arm, shoulder, and back pain. These symptoms are lessened with exercise (I am in Cardiac rehab). These started almost immediately, and are fairly constant. I talked with my doctor, and because the last a long time, and don't worsen with activity, they say it is not heart-related. The worst part is the uncertainty of what is causing the pain. I wish someone would make doctors aware of these issues!
Ken R., Georgia, USA, October 17, 2007

• All, I am a 40 year old male with 15 Cypher DES stents and a special covered stent to address an aneurysm in my LAD. My first operation last year placed 8 Cypher DES stents - 5 in my LAD and 3 in my RCA. The recent stents were placed in my RCA and LAD in some of the locations that had restenosis, and new stents in my Circumflex. I had a severe rash last year when the first 8 stents were put in. My cardiologist, Dr. Samuel DeMaio in Austin, TX is a research cardiologist and a patient advocate (he is an MD, a lawyer, and a electrical engineer - quite a career - and is involved heavily in research cardiology). When I had the rash response, which was also accompanied by severe itching to the point of driving me mad, he placed my on Zyrtec. I took the medication for about 2 months and it worked very well. When I quit taking it, the rash and itching did not reoccur. After the last set of operations this year, I never experienced the itching and/or rash so I never required the treatment with Zyrtec. Zyrtec is a drug used to treat allergies. I worked very well for me. By the way, I exercise almost every day - weight lifting and cardio. The benefit of weight lifting - if your doctor deems it safe for you - is that it appears to improve heart rate recovery.
Gerald Merits, Austin, Texas, USA, September 7, 2007

• I HAVE READ EVERYBODYS BLOG AND I HAVE THE SAME FEELING THE BURNING SENSATION, THE ITCHINESS,THE URINATING PROBLEM, AND THEN THEY WANT TO TAKE ME OFF THE PLAVIX! I GOT THE WHOLE BENEDRYL & PREDNISONE THING WHAT ELSE HELPS? ANYBODY HAVE ANY ANSWERS? I AM ONLY 32 YEARS OLD.. I FEEL LIKE IM GOING CRAZY.
DAN, GEORGIA, USA, September 6, 2007

• Jo brings up a good point about what happened to her husband. When a Thrombosis(blood clot) is formed in the stent can it and will it move around in the heart. It would only make sense for this to happen, however I would like to have clarification. Thanks again for all you assistance.
Bob Puckett, , Snellville, Ga. U.S. A., August 07, 2007

• Jo D -- curious as to how long after getting the Cypher stent did your husband stop taking Plavix. And who told him that was okay to do? His cardiologist? We hear your frustration with the healthcare situation -- but stents have also helped many people, and we would say that in the past year, the pendulum has swung quite far in questioning the use of drug-eluting stents -- many feel too far. Reading over your story, it's not clear in what way the stent your husband got caused any problem, since his thrombosis occurred in a different artery from the stent, according to your doctor. Did your husband get other help, such as rehab or a program of lifestyle changes (smoking cessation, diet, exercise, etc.)? Did you know that studies have shown distance truckers have higher rates of coronary artery disease?
Forum Editor, Angioplasty.Org, August 6, 2007

• My husband has had 5 by passes in 2000, He did not have a heart attack. The only medication he was on was aspirin and lipitor. Then in 2005, he was having pain down his arm , he is an OTR driver. He was away from home, he went to a hospital in another state, they ruled out a heart attack, but ran dye to find a small blocked artery. They put in a Cypher stent, put on plavix for 9 months or longer. His doctor let him stop taking plavix, two month later he had a heart attack from thrombosis, however, the doctor said it was because he stopped taking plavix, but he said it was not caused from the stent, because it was a different vein. now he is on plavix, lipitor, and toprol, he had never had high blood pressure before the drug eluting stent, yet the cardiologist says it his problems had nothing to do with the stent. I have to ask, money talks and I feel these stents have caused problems for a lot of people and the doctors benefit from the stents because the drug companies spend millions on them to push their products. The FDA must also benefit from the large money drug companies. Do they have any idea what kind of trouble they are causing these people trying to keep jobs with insurance and the companies don't want to employ these people, it is a serious situation for many people and our government does not seem to care. All I can say is thank god there will be a time when everyone is equal and money can't buy anything!
Jo D., Oklahoma, USA, August 2, 2007

• Greg and T.C. -- we can understand your frustration and worry. As we've stated numerous times, there are many different possibilities for the type of reactions described in this Forum Topic. It is difficult to discern what is a drug reaction and what might be something else. As for the "something else", little research has been done on this phenomenon. Hypersensitivity (or allergic reaction) to the coatings (a.k.a. polymers) that are on the Cypher or Taxus drug-eluting stents has been the subject of only one peer review article -- it was published in December 2005 in the Journal of the American College of Cardiology (see our piece, "Drug-Eluting Stents May Cause Allergic Reactions"). Already at that time, we had numerous postings on our Forum from patients describing symptoms like yours. A year ago, the group of cardiologists who wrote that article came to Angioplasty.Org to see if we could refer patients to them -- they were quite sure that such a sensitivity existed, albeit an extremely low incidence, and were trying to develop a test to confirm such a reaction in patients. We have been referring patients on this Forum (see the right side-bar) to the study, but the cardiologists have been hampered by lack of funding and no assistance whatsoever from the two FDA-approved device manufacturers -- they actually have to purchase the stents retail in order to obtain material for allergy testing. These were matters that Angioplasty.Org communicated to the FDA -- most recently during the FDA's two-day DES safety hearing in December 2006. We also feel that the hypersensitivity reaction may be an indicator for increased risk of late stent thrombosis, but this is only an unproven hypothesis. By all means, contact us regarding the Stent Allergy Study, and feel free to write the FDA and your representatives in Washington about this situation. On the brighter side for patients is the fact that the next generation of drug-eluting stents, in particular the Endeavor stent made by Medtronic and the Xience made by Abbott, use different polymer coatings that are supposedly more biocompatible.
Forum Editor, Angioplasty.Org, July 21, 2007

• In Dec. 2005, I had a Cypher stent placed in my proximal LAD after an MI at age 38. I have had dull chronic chest pain ever since. I have had two subsequent angiograms, one even with IVUS, and everything looks great and the artery has great flow. I have seen experts in three different university centers and none of them has an answer. The dull chest pain drives me crazy at times on days when it is particularly bad. I have always had a healthy diet, nonsmoking, athletic, person with no family history or other risk factors. My last doctor was the most thorough and he thinks it may be a local inflammation/allergic reaction to the stent coating. Up to this point I had ruled out allergic reaction because, unlike most accounts, I have had no other symptoms, of an allergic reaction (skin rashes or hives). However, the doctor described cases in which pathologists have performed autopsies on people who had once received drug-eluting stents and discovered signs of local inflammation. I wish Johnson & Johnson, and other stent manufacturers, could provide very small samples of the drug used on the stent for allergists and other doctors to do skin tests to help identify the cause.
Greg K., Nevada, USA, July 20, 2007

• Last August my mother had a medicated stent inserted. Since then her health has constantly declined. All along she has said she felt better before the stent was inserted. She had a rash after surgery that was explained as being a reaction to the Lasix medicine she was prescribed (even though she had taken it before without any problems). She was also put on Plavix. She complained of pains in her neck and throat and excruciating pain in her back and leg. She slowly lost her appetite and in December she was forcing every mouthful down. End of December she was prescribed Edecrin for fluid since everyone thought she was allergic to Lasix. From Jan 1 to April 30th she was in the hospital 3 times. The last time was over 30 days with severe vomiting and diarrhea. Nothing helped! Needless to say she was down to nothing but skin and bones. Finally after inserting a feeding tube we were able to bring her home. Every test that has been run has come back negative. Everything looks great and the doctors can t find anything that's causing her problem. Since discontinuing the Ederin in May, the vomiting stopped but her health still hasn't improved. Before the stent she was a dynamic 76 year old. She was very active. Always on the go and doing things for others. Now, she barely speaks unless you ask her something directly. She s able to slowly walk from one room to the other and that s all. I found this website searching to see if anyone else had experienced the same problems as mom. Has anyone found anything that can be done to help people whose system can't tolerate these stents? Mom is slowly slipping away from us.
T.C., Florida, USA, July 7, 2007

• Chad -- if you read through these posts, you'll see others worrying about nickel allergies writing in. Whether or not this is your wife's problem is something that you should discuss with an allergy specialist. That being said, we refer you to our posting from April 10, 2007. Stents that contain surgical stainless steel all carry a warning to physicians in their package insert that patients with a known sensitivity to stainless steel or nickel may suffer an allergic reaction. And this applies to all stents, not just drug-eluting stents. There are some stents made with titanium, but they are usually a titanium-nickel alloy. You've raised an important issue and a problem. Patients who are potential stent candidates should be asked about allergies -- certainly all patients need to take the initiative and make their physicians aware of this condition because many surgical implantable devices are made with nickel. Your allergist may be able to recommend some form of therapy. Please let us know how you fare and thank you for writing in.
Forum Editor, Angioplasty.Org, July 3, 2007

• in short 12 heart caths in 10 years for 11 stents placed total. 1 triple bypass at the ten year mark. Is there a possibility of a nickel allergy causing all of the heart caths? My wife has a severe nickel allergy. 7 months after the triple bypass she had to have the wires removed from her chest because they contained nickel. We recently learned the all of the 11 stents have at least 2%nickel in each. She has been diagnosed with multiple illness that are possible linked to an allergy to nickel. Her health is quickly getting worse with no answers as to why. My thought is the elevated levels of nickel being released constantly from all 11 stents. Cardiologist says impossible, By-pass surgeon says absolutely, primary physician says yes also. If so, why were we not informed of nickel in the stents even though we asked every time. Doc's always answered 100% titanium. How to reduce the effects of the nickel?
Chad Lehan, concerned hubby, Spokane Washington, June 24, 2007

• Thank You Terrie Blanton [May 6, 2007] for your post. I have been in contact w/ a Dr. at University of Texas. But as of yet haven't been accepted for the study. My GP is checking on some things before I send the paper back stating I want to participate in the study w/ my signatures on them. This seems to be a long process to me. I found this site in March of this year and sent a request that month.This is early June and I really hope the process speeds up soon. I don't hope to give other people a negative impression of the study. Apparently I assume it does take time to get accepted and get the actual study started. But to me every day that goes by seems like a long time dealing w/ the joint pain and rashes and now off and on itching. I estimate I have been dealing w/ the problems for 4 years now and feel worn down or out from it all.
Paul T., Illinois, USA, June 2, 2007

• Since my stent placement DES I have been losing weight and it will not stop. I have lost approx. 38 pounds in the last 5 months. Has anyone else encountered this problem?? If so, what was the cause if you know?
Norman Z., Michigan, USA, May 16, 2007

• Hi everyone; greetings from Down Under. I had a BMS put into my RCA eight years ago. I was only 46 and till then very fit and healthy. I did not have a heart attack, but suddenly developed angina and coronary artery cramps. During an angiogram my RCA was called as being 99% blocked! For two years afterwards, I felt as though I had someone inside my chest repeatedly jabbing me with a knife, or similar sharp object. It was disconcerting, to say the least. I also developed severe tinnitus. However, all the pains gradually subsided and became very intermittent and I learned to live with it. The more active I was, the better I felt. Unfortunately, the ringing in my ears persists to this day. Some say the meds are the cause, others say no. I just live with it and get on with things. Three months ago I had a sudden heart attack and the BMS reblocked. I was so bad I was flown to Melbourne (the capital city of Victoria) by helicopter. In the cath lab they called my RCA as 99% occluded again. Now, that was a close call! They tell me the damage to the heart is minimal, but I probably wont be able to climb Mt. Everest. Ever since, I have been feeling a million dollars. For around three weeks I would suddenly get very tired during the day; like running into a brick wall. So, I would have a sleep, maybe for a half hour, maybe for a couple of hours and then I would be fine again. Now, I feel great. No pains, no aches and I can chase my kids all round the park and apart from being so out of breath after a chase that I am leaning on a fence gasping for air, I have no ill effects. In fact, the more active I am, the better I feel. The sad part of this story is that just prior to my heart attack, I stopped taking my medications - Plavix included. I was doing some high stress work for the Federal Government, often in isolated areas and just not able to get to a Doctor to get my prescriptions renewed - and I paid the price. They now have me on aspirin as well as the Plavix and I am aspirin intolerant. Aspirin gives me very, very severe indigestion. Fortunately I may only have to take it as an adjunct to Plavix for a year. I am now trying coated aspirin. Don't forget, that a stent is a foreign object in the body. Some bodies react very badly to foreign objects. Mine did and hence all the weird and wonderful pains after I was given the BMS. The new stent is a Cypher DES and it is inside the old one. It is designed to slow down the growth of cells and so, logically, the body can't react to it the way mine did eight years ago. Consequently, I am amazingly comfortable. Amazingly, I am still fit and active. My kids are still very young ( the youngest is only six) so I have to be. Again, the more active I am the better I feel. What is often not addressed, is the psychological aspects of heart problems, particularly when invasive surgery has taken place. You feel invaded and you know the problem is very serious, because that's why the doctors intervened. In a nutshell, it's all very scary. I try to just get on with it,stay positive, ignore aches and pains if they surface and be as active as I possibly can. My indigestion is nothing compared to the possibility of being in a cemetery. Never again will I forget my pills and tablets for any reason. I take my hat off to modern medicine, because with out it, I wouldn't be here.
John Keily, Rosedale, Victoria, Australia, May 16, 2007

• OK, it has been over 5 months since my one stent DES was put in and I am still feeling very tired, weak, chest pain, etc. I am curious as to, is this the way life is now going to be forever?? Are people that are having these symptoms, dying off?? What is going on? Please let us know.
Norman Z., Michigan, USA, May 15, 2007

• Anna -- certainly if you don't feel well, you should discuss this with your doctor, preferably the interventional cardiologist who stented you. But your symptoms may not be related to the stent. Allergic reactions to stents are uncommon, but obviously, as this Forum attests to, some are experiencing them. More common are side-effects from drugs you may not have been taking prior to the stenting. For example, ACE inhibitors sometimes cause coughing. Statins can cause muscle and joint pain. As for worrying, there's a new study out this week that worrying can definitely affect heart health and that doctors should be more attentive to helping with this. Often an adjustment of medications can make a major difference. Let us know how you fare.

And Terrie from Ohio -- thank you so much for updating us all on your experiences. We too hope the Texas study reveals some information. This is a problem that obviously some patients are experiencing. Even though it may be rare, it ain't rare if it's you! We second your call to others to continue posting and updating this Forum -- it's just about the only place where this issue is being discussed.
Forum Editor, Angioplasty.Org, May 15, 2007

• July 6th of this year I had 3 Cypher stents put in the LAD. Ever since I have not felt well. Chest discomfort, coughing, and constant worrying. I have also gotten some fatty tumors so they say that's what they are on different parts of my body. I was reading the book the other day that came with the card to carry, because of the stenting and I read that the medication that is in the cypher stent Sirolimus can cause tumor formation, also joint pain. I was wondering if anyone has noticed that they have gotten any fatty tumors since they received the stents and didn't realize that this may be what they are from. I'm at my wits end. I was also wondering if I should mention this to my doctor. I don't want to look like I'm nuts. But this does seem to make some sense of why I have these tumors and are they really just fatty tumors. I would appreciate any insight you may have. Thanks, Annie,
Anna, Parkton, Maryland, USA, May 8, 2007

• Back once again with a update to my previous posting of November 4, 2006! Bill has went through the testing with the University of Texas for possible stent allergies. He had a slight reaction (redness of the skin), his doctor said it was too slight to indicate a reaction. He then had to have a nuclear test on his whole body to check for inflammation. This test showed inflammation in the area of the mouth. The doctor's don't think this has anything to do with the stent because inflammation wasn't found anywhere else but have no idea what is causing it. The doctor said he is sure it is not the stent but still can't rule it out. He also said he could not remove Bill's stent because of where it is in the heart. The doctor also said there are no more tests to run on him and the only suggestion he could make is to go on a low dose of a prednisone and if it helps he may have to stay on it the rest of his life. Bill is not considering this at this time. Bill has had problems with his mouth, sore throat, hoarse and all kinds of skin problems which started with the stent. The last 3 weeks he has been able to use polygrip for the first time since the stent. Everything else is the same-symptoms come and go.

The tests and films were sent to the University of Texas a month ago and they are to let us know what they think of all this. We found out from a friend of ours that has the same doctor as my husband that our doctor told him Bill is a rare case. He is allergic to something in the stent. He has had other cases but the symptoms usually go away after 6 months but Bill's hasn't. After 20 months I have little hope he will get better. Bill's doctor has never told him what he told this other person but still says he is sure it is not the stent but can't rule it out either. Bill has told his doctor all along he thought it was the stent. Now, at this point in time, it has to be the stent or some weird syndrome caused from plavix, etc, that he was on for awhile. Bill and these other people on this forum are not from the twilight zone with some alien disease. In my opinion, Bill's doctor has known this forever and we have just been on a witch hunt. Bill and I are where the doctors want us - giving up and just dealing with it day to day on our own. They can't do anything about it so just go away and deal with it. As for the medical profession there has been entirely too much miscommunication, no communication and poor ethics. If we hear from Texas University we will let the forum know. I think the study in Texas once completed may give us some interesting data but that is probably a year to 2 years in the making. I hope others follow through with the study as it may be the only hope of any answers for us on the forum. Thanks again for listening and would love to hear how some of the forum group is doing that we have not heard from in a long while.
Terrie Blanton, Hamilton, Ohio, USA, May 6, 2007

• Linda -- when you say "blood clots", we assume you mean blockages? It sounds like what happened was that your husband went for a diagnostic angiogram -- a test to see if his arteries had blockages. One question is why he saw the cardiologist in the first place? Was he having symptoms? Chest pain? In any case, usually cardiologists tell their patients who are having an diagnostic angiogram that if they see a blockage that definitely needs opening up, they can do it right there and then, adding only 20 or 30 minutes to the procedure, rather than bringing them back on another day and going through the whole needle puncture of the groin artery etc., all over again. Sounds like you and your husband did not understand this -- sounds like better communications were needed. (By the way, angioplasty/stenting is technically not "surgery".) Anyway, here's our recommendation, because we (or any other internet site) should not be giving out medical advice. Talk to your husband's cardiologist. Let him/her know that you were disturbed when you found out that an intervention was done and that you weren't prepared for that. Maybe they'll say it was in the consent form -- and maybe it was -- but the fact remains, you weren't prepared for it. But communications aside, don't let the problems that your husband is experiencing go unreported. Some of the symptoms you list may be drug-related (drugs often affect the elderly more, and tiredness, shortness of breath, and especially bleeding, if your husband is on Plavix and aspirin, are drug side-effects. But DO NOT (that's capitalized for a reason) stop or change your medications without discussing this with your husband's cardiologist. Stopping Plavix, for example, can be very dangerous. It is unfortunate that he (and you) feel distrust at this point. But it sounds like you have a reason. Poor communication may not seem like a big deal, but sometimes has profound effects. Maybe this can be resolved when you explain yourselves to your cardiologist. We would hope so. And that as you go forward, adjustments to medications, etc. can be made, and that you and your doctor can work together to achieve a better result. Please let us know how things go. And thanks for sharing your story.
Forum Editor, Angioplasty.Org, May 5, 2007

• My husband is 85 years old. He has high blood. Last year November 27, 2006 the heart doctor stated that he needed to go to the hospital as an outpatient to check and see if he had any blood clots. We did exactly what the doctor stated us to do that day. The next thing we knew he was having surgery in which we was not inform of by the doctor. He stated that he just wanted to check to see if my husband had any blood clots not surgery. Anyway we was betrayed by the doctor and now my husband is having a lot of problems since that surgery. The doctor stated that he had two blood clots but they could only unclot one because of his age and health condition. Now today he suppose of went back for the second blood clot on April 3, 2007 but my husband is afraid to go back to the doctor. Now he's having more difficult problem breathing; tingling in the hands and feet; coughing up blood; nose bleed and running nose constantly; constantly belching and chest pain; feet swells up; sleep all day; tired and depress; lack of memory forgetful; lost of appetite etc. I do not know what else to do for him because he's afraid of any doctor now and I cannot get him to go back for a checkup on this follow up from surgery to find out what is going on with his health. We don't know if he has the Drug-Eluting Stent or the Bare-Metal Stent that could be causing Allergic Reaction or Side Effects.
Linda Jones, Fresno, California, USA, May 4, 2007

• Brian H. I just want you to know that I too had tingling in the hands and feet and it finally went away. It took about 3 or 4 months before it went away. I too still have some symptoms of discomfort and am taking place in a stent study in Texas. Please let us know how you are doing.
Norman, Michigan, USA, April 30, 2007

• Lisa from Traverse City, Michigan. I had a stent put in after taking Plavix for 10 days. A month later I began having terrible continuous belching, so loud people in the next room could hear me. The doctors finally decided after 2 months that I had an infection in my stomach.
Bernie, Illinois, USA, April 18, 2007

• Has anyone out there experienced unexplainable burping after being put on plavix? My father-in-law had a stent put in last fall and then put on Plavix. He has this burping that is a mystery to the doctors in our area. Any ideas???
Lisa, Traverse City, Michigan, USA, April 17, 2007

• i am a 55 yo male with 6 stents and double bypass. 2 stents were put in after the bypass. the last 2 were taxus stents. the stent clogged up 21 days after the insertion. i have constant chest pain and my blood pressure goes up and down, with the high so far was 232/126. i am constantly tired and depressed, so depressed i left my wife because i felt like i was no good to her. the last stent was put in the 1st septal [branch] which caused the mi and my doctor stated he had gotten into a lot of trouble by the head of the cath lab for putting the stent there, why do doctors do this? i am totally disabled due to the pain and breathing prob.
Ray G., Maryland, USA, April 13, 2007

• Thanks for your quick response. I have just talked to my doctor's nurse who tried to tell me that stainless steel did not contain nickel, and that if I had concerns, the doctor would not perform the procedure. (I think I was fired as a patient?) I am suppose to contact her with my decision to proceed this afternoon.
Jean R., Tennessee, USA, April 10, 2007

• Jean -- Please be advised that we are not doctors and thus do not offer "medical advice". Any information or opinion from our web site should not be used as a substitute for medical advice from a licensed MD. That being said, we can tell you that all medical devices come with a DFU (Directions for Use) which is produced by the manufacturer and required by the FDA. Pretty much every DFU for stents which are made of stainless steel (which also contains nickel) warn that in some patients, these devices may cause allergic reactions to the metal. For example, the DFU for the TAXUS stent reads, under WARNINGS: "Patients with known hypersensitivity to 316L stainless steel may suffer an allergic reaction to this implant." The Cordis CYPHER stent (as well as most bare metal stents) have similar warnings. A web page from the FDA that addresses this problem can be found at: http://www.fda.gov/cdrh/medicaldevicesafety/tipsarticles/allergies.html Hope we've been of help. Good luck.
Forum Editor, Angioplasty.Org, April 10, 2007

• I had a heart catheterization last Thursday and they want to proceed with a stent later this week. After doing my homework and realizing the stent is made of metal containing nickel, I called my doctor's office and informed the nurse of my severe reaction to nickel. She indicated that she had not heard of a problem and would check. No one has called me back. Should I be concerned, should I cancel the procedure. Help.
Jean R., Tennessee, USA, April 10, 2007

• I recently sent this letter to the Stent Study group. Hope it helps someone. Correspondence welcome:

• My husband had 6 DES stents implanted in April 2006. In September he started developing a rash, started itching, etc. He has seen a dermatologist, has tried several meds, creams, etc. Nothing works. Please forward us any information you may have regarding the study, etc. Thanks.
Joyce P., Indiana, USA, April 2, 2007

• My father in law has been seeing his cardiologist and working on a eliminating various drugs from his system, one at a time, since this started. They did replace Plavix with another drug quite some time ago, with no success. They have since then replaced other drugs in his repertoire (he has about 12 total to control his heart condition, diabetes, arthritis, blood pressure, etc.) That is why his case is so complicated. From reading the forum and the fact that the rashing started about 3 days after surgery, we are suspicious it is a stent allergy. Especially since he has not responded to the drug elimination. In addition to this, no steriods or other anti-itch medications have been able to help him. He also had a great deal of swelling in his legs and constant water leakage. The water leakage has been controlled at this time by the use of ace bandages. Your study seems like something we would be very interested in. Especially since it is only a skin test that his doctor can do. He actually has an appointment tomorrow. We will bring this email in to show him. I will also contact the stent allergy study.
P.A., Maryland, USA, March 24, 2007

• Elaina and Bob -- your suspicion is a good one, although it is very hard to say for sure, which is why the group of cardiologists who first described the hypersensitivity reaction to drug-eluting stents in the Journal of the American College of Cardiology are now engaged in a study to find out more. The reactions you describe are similar to what has been posted on this topic here and what the cardiologists have seen. We encourage you to email us for more information on the study. They may be able to identify the source and help.
Forum Editor, Angioplasty.Org, March 14, 2007

• I too am one of the people who suffer severe joint pain. I do have arthritis, but since the taxus DES's were implanted I am getting to the point that Its really tough sometimes to even walk. Getting off the sofa sometimes can be a chore because of the pressure I have to put on my knees. My son even bought me a cane to help me walk. I also take plavix and aspirin everyday, I have for 22 months but am scared to come off because I have already had stent thrombosis once, and believe me, I don't want it again. I'm glad to be alive, but didn't know I was going to have to suffer this much. My hand even aches as I type this.
Bob P., Snellville, Georgia, USA, March 12, 2007

• My husband is 54 and had a stent put in 18 months ago, and at a year he broke out with the worst hives and rashes and welts all over his body even the palms of his hands broke out and itched. He also gets congested in his lungs and a low grade fever. We have been to our family doctor and dermatologist. For the past two months, all they give him is shots of steroids and oral ones to take at home. If he tries to go off of them it starts all over again. This is not and environmental allergy it is coming from inside his body and the only thing in him is this stent. Now they want to test him for allergies but this is not a typical allergy it is so severe. Has anyone else had this after having a stent for over a year? We have been to five different doctors and they can't figure it out. I really feel it has something to do with the stent. Is this possible?
Elaina , North Carolina, USA, March 11, 2007

• George -- thanks for writing in your positive non-allergic experience. It's a good reminder that having the kinds of reactions one reads about on this Forum topic is not what everyone experiences. In fact the vast majority of patients don't experience these problems. That being said, the reason this Forum exists is to give a voice to that minority.
Forum Editor, Angioplasty.Org, March 11, 2007

• Adding my experience. A DES was inserted into my Left Anterior Descending Artery on 2 March due to 95% blockage. For the record I felt better within 12 hours of the procedure. I returned to a strong powerful feeling in my chest. My stamina is way up to last year's levels so I have to watch my exhuberance to drive up to my past peak. I am one of those anomalies. Health conscious, don't eat fast food, maybe ate pizza 4x per year, usually eat oatmeal yogurt, that sort of diet. Until I broke my ankle last year I was cycling 3x week @ 20-30 miles each and did strength training. I am describing myself because I had no heart damage whatsoever. The cardio guy said my heart muscle had extra circulation from my aerobics. So the stent essentially opened up the flow. So far no sensation in my chest or the Aspirin/Plavix/Tomoprol/Vytorin regime. I have further changed my diet to that of a cow.
George, Clermont, Florida, USA, March 10, 2007

• Dear Forum, Thanks for sending information about the "Stent Allergy Study". It's good to know someone (a cardiologist) is studying this possible allergy. Yes, my stent was a drug eluting stent. I may have only had 1. They had talked about 2 but it may only be 1. The drs. seem to find an explanation for these problems but I know I haven't been the same since the stent placement. I had hoped to be a model heart patient if there is such a thing ha. By doing all i was told would be good for my health and heart, but it hasn't worked out that way, unfortunately. I will talk to my Dr. again about possible allergy when i see her and also let her know about the study. Then I may email the cardiologist who is doing the study. BY the way, what is the side of the drs and cardiologists on the subject of stent allergies? It might be good to see both sides patients and Drs. Thanks,
Paul T., Illinois, USA, March 6, 2007

• Thank you so much for returning my email with information about a possible allergy to the drug stents themselves. My mother had two drug eluting stents put in in October 2006 and immediately started having allergic reactions,including hives, rashes, itching, joint and nerve pain. Her cardiologists took the normal course of action to see if this reaction was to her Plavix. Six months later, my mom has been on Plavix, Clopidogrel, Ticlid, Altace, and a variety of others and her allergic reactions have not ceased. She is being treated for these reactions, but the cardiologists have come to the conclusion that she is allergic to the stents themselves. My mother does have a history of severe allergies to medications. Mom's condition is getting worse and she was told she could be looking at having more stents put in. She is refusing this because of the "nightmare" she calls it of the last 6 months of allergic reactions. Any information you can provide is extremely helpful and please put my comments on your forum, including this one today. Your forum has already encouraged mom because she now knows she is not going through this alone. Thank you for all your help.
Kathy A., Oklahoma, USA, March 5, 2007

• had mi in nov 05, had 2 stents placed in LAD, not sure if bare metal or des.For last 12 months have had continual lower chest and back discomfort,i.e. soreness, feels like a rash, but not showing on skin. Had 2 stress tests, both negative, cardiologist has no idea what it is. If I lay down symptoms go away, but I still have them sitting down, any thoughts anyone?
Ken, London, UK, March 4, 2007

• My companion had two stents implanted in Nov., 2007. He experiences lethargy, "funny feeling" in chest, heartburn, hiccups. His blockage was 70% and he felt well before the stents. Now he sleeps and is unable resume normal life-style. He takes Plavix and regular strength aspirin. Symptoms were so bad one week after surgery that angioplasty was done to check stents, with no problem found. Any help appreciated.
B.C., Kentucky, USA, March 3, 2007

• Steve Florida - Thanks for your response, glad to tell you my history - in december 2005 I went to my doctor (GP) with the following symptoms tightness in the chest, weird pain across the shoulders, and pain / weird feeling of numbness/pins & needles in left arm & severe discomfort in the throat/neck, all this when I walked & occasionally when at rest. He diagnosed possible Angina & put me on Bisoprolol 2.5 mg and sent referral to cardiac dept in local hospital, for some reason as yet not known I did not get to see a cardiologist until October 2006 when I had an exercise test (which showed a problem) from then on things moved a lot quicker, at the end of November I had an angiogram - this showed the right hand coronary artery was almost blocked (90%+) but this side of my heart was being partially fed by what they called backwash from the left side, it seems I had developed small blood vessels to feed the right side (this is not unusual so I'm told) It seems my doctor (GP) putting me on the beta blocker (bisoprolol) stopped a possible heart attack. I was admitted to hospital on 31st January 07, went for balloon angioplasty & stent on 1st Feb - I went on the table @ 9am all ok until contrast dye was injected when I had allergic reaction to this iodine based product - this was sorted OK - artery was totally blocked, cardiologist opened this with the balloon and placed 2 DES - went back to the ward and felt better straight away - no more pain since, I take plavix, simvastatin - aspirin, (stopped Bisoprolol 2 weeks ago) I should point out that during the time I waited for angiogram I could only walk about 50 - 100 yds without pain/indigestion - nitroglycerine spray only gave severe headaches.
David W., England UK, March 2, 2007

• David W from England: Thank you very much for posting a response. You are indeed the first person I personally ever heard of who actually felt better after a DES stent was implanted. And I have communicated with dozens and read hundreds of posts all over the internet. Your post did make an impression on me. If anyone else has had a true benefit in chest discomfort from a DES stent, please also post. I and all of us would of course like to hear from you too. It at least gives us hope, and an interest to make sure there are no other causes of any chest pain or other problems. My problem of constant chest pain started immediately after the DES stent was implanted. David, your stent is apparently very new. Did you actually ever have a heart attack? Or just a stent on a doctor's recommendation. What exactly were your symptoms/problems before the stent was implanted, i.e., med history? It has been posited that if one had an MI, then the results of DES stenting are far less beneficial, and chest pain may actually increase substantially. How much better are you? Your post was very brief. Very curious. Thanx.
Steve, Florida , March 1, 2007

• Eli -- the original purpose of angioplasty was to relieve angina. If you are experiencing angina more after stenting than you were before, then something is not working right. Have you had a followup angiogram or other test to determine if the stent is functioning correctly? Also check out our related topic called, "Not Feeling Well After Stenting".
Forum Editor, Angioplasty.Org, March 2, 2007

• hi i am 44 yrs old and live in uk . i had a heart attack in nov 06 and a cypher stent placed on 2nd feb 07. My problem is i am in so much pain with angina now than what i was before stent was fitted. before i had the stent i could cope with the pain but now it seems to be there most of the time and radiates down both my arms it makes me cry, the pain is waking me up at night too. i was admitted to hospital put on infusion of nitro which helped but was discharged with pain killers next day i couldn't believe it. i have since paid private to see a cardiologist and have been given isosorbide mononitrate this doesn't stop my pain completely but takes the nasty edge off it and makes it easier for me to tolerate. i wish i never had the stent. my life has changed so much i cant do what i did before i hate it . could this be an allergy to the stent or unstable angina. thanks
Eli, Sheffield, England, February 28, 2007

• Dawn -- check out the right-column side bar. There is a group of cardiologists in Texas who are conducting research on hypersensitivity to drug-eluting stents. They are developing a protocol for testing this and are looking for patients who may be experiencing these kinds of unknown symptoms post-DES. Click on the email link and we'll send you contact information.
Forum Editor, Angioplasty.Org, February 27, 2007

• Hi everyone, I have posted here before. Still having issues related to skin, others have mentioned rashes. In my prior posting I noted that I have what appears to be a rash but the dermatologists are calling it Granuloma Annulare. Has anyone else with rash or rash appearing marks gone to dermatologist? and gotten same diagnosis. They still say they don't know for sure what causes it and I really do feel it is related to the stents I have. I have known metal allergies to anything other than gold and sterling silver. I went to Mayo and their diagnosis was the same, when I questioned the metal stents or the medicated stents as factors, they quickly said "No" but for not knowing what causes this they sure did not ask questions to try to find connections between those that have this Granuloma Annulare. A gal I know, her husband had medicated stents after I did and she said he has developed a rash that looks like mine but on his chest. Does anyone out there have the same?
Dawn Reich, St. Paul, Minneapolis, USA, February 26, 2007

• I wonder if anybody found any over the counter help for the rashes. I have two stents and three rashes -- one on each ankle and one in the middle of my chest which only recently seems to have cleared up. Both of the remaining rashes are small, round and refuse to go away. Web searches have told me nothing (and no, these are not ringworm or Lyme disease related). I also have the in the ear, behind the ear, around the eyes and around the nose dry/flaky skin so any info for that would also be helpful...
Robert, February 21, 2007

• To Steve in Florida, Feb 12 -- I think you may be getting a distorted view of the viability of the DES, Forums usually only seem to attract people who have had problems and are looking for a way to resolve them which is perfectly understandable, most people go to a forum looking for answers that they are not getting from their doctors. I had 2 DES fitted 2.2.07. and it is like a magic wand has been waved, no more angina pain, I can walk for miles with no discomfort (as opposed to 50 yards), I do need to regain some fitness as I have been almost inactive for over a year but that is coming back slowly, I have very mild 'cold / flu' symptoms that may be side effects from one of the drugs but I can live with that,other than this all is good so far.
David W., England UK, February 21, 2007

• Cheryl -- it's not correct that the "drug dissolves in two weeks". The Cypher has a "nominal elution period" of 90 days, although most of the drug is eluted in the first 30. The Taxus also elutes a controlled dose in the first 30, although, depending on the version used (slow or moderate release) 70-90% of the paclitaxel drug stays in the polymer (is never eluted). But the polymer (plastic) coating stays on the stent. With the current Taxus or Cypher, it does not degrade and the cardiologists who are studying allergic reactions to DES are pretty sure that it is the polymer coating that is causing the allergic reactions. The protocol they have developed for their study is pretty straight-forward and can be administered by a family physician -- it involves stopping meds one by one, but only under their protocol for safety reasons. Then a special skin test is done and the eosinophils are measured (a type of white blood cell). A nickel allergy will not increase the eosinophils.

And Steve from Florida -- you've posted a number of times and we hear you -- especially that you've had nothing but trouble. There are problems with these devices in some situations, which are being identified. But your blanket statements about stents being harmful to everyone and that no one has ever been helped by them is just not correct. Six million people worldwide have been stented -- the big picture results don't show a catastrophe in the making. A close friend of ours would not be alive today if stents and angioplasty did not exist. However, there is no question that DES have been over-used in this country. That is now changing -- and newer hopefully better second generation devices are coming. Surgery has its downsides as well, for example, impairment of cognitive function is a well-documented side-effect of bypass surgery.
Forum Editor, Angioplasty.Org, February 20, 2007

• Well I am back posting because even the Mayo Clinic has no idea how to help my friend. Cardiologist is sorry this has happened to her, but there seem to be no answers for her. The testing has been extensive and even the cardiologist agrees since nothing else is wrong with her then it probably is an allergy to the nickel, you will note I said PROBABLY..even after all tests came back negative no one is willing to admit that this is an allergy. Where do we go from here??? The one suggestion was for a pain study group, but she has been to a pain specialist group before and their only suggestion was for morphine which is something she is not willing to do. The "storms" appear to be happening less frequently, but I have also suggested she use COQ10 and magnesium as supplements to some of the other medications she is on, since so many of the medications she is on cause muscle and joint pain. The swelling of her joints does appear to be a little more bearable, the rash is still an all over rash to include her throat (which children's benadryl seems to ease), but how much benadryl can one person take? I feel so strongly that this allergy is something that should be considered for every single person that is even discussing stents with their doctors, I have spoken to several people and just my random discussions seem to prove to me that a significant number of people suffer from this allergy. I have discussed the stent allergy study to her, but I am not so sure that she is interested in being subjected to more testing, she is pretty fed up with doctors right now. She also is not having a reaction to the drug on the stent, she is having a reaction to the nickel in the stent. She has been told that the medication on the stent dissolves within two weeks of the procedure, so she knows, or feels relatively sure the reaction is to the actual stent which cannot be removed.
Cheryl, Phoenix, Arizona, USA, February 17, 2007

• Update to the Forum -- My cardiologist is changing my meds to Ticlid, although I have to wait for it to arrive at the pharmacy. After seeing my PCP yesterday to check my rash, he recommended that I not discontinue the Plavix until I had the Ticlid. He suggested that I may like Claritin better as it would not cause the drowsiness of the Benadryl (I was taking 50mg). I did take the Claritin, as well as quartering the Plavix tablet and taking the quarters over a period of a couple hours. Currently, the rash has almost disappeared, and the itching is well within tolerable limits. The Ticlid has not arrived at the pharmacy yet, and I am now considering continuing the Plavix a while longer to see if my body will adapt (I am encouraged by the University of Iowa study). The Dr informed me that the Ticlid comes with a requirement of CBC blood tests every two weeks and they would leave me on it for 3 months. The plan for the Plavix was for 12 months minimum. They also plan a nuclear stress test in 3 months, to be followed by another catheterization to check on the stent's progress. If it turns out that the rash returns after changing to Ticlid, I will contact the stent allergy study. Thanks for your response and your forum.
George C., Florida, USA, February 13, 2007

• I have talked to dozens of DES stent recipients, and read hundreds of posts on all kinds of heart related web forum sites, in addition to this PTCA site. There are many heart related sites on the net. I have never talked to or read a post from anyone at all who actually said that their stent made them feel "better", or that they truly felt the stent overall improved their condition. (Though their doctors may have told them so). All have told that their DES stent(s) made them feel much worse. I have only read of one single person (personally) who simply said their DES stent left them "about the same", but not worse. I think those reading this will have had the same witness of reports by those they have talked to about their stent experience. It almost always bad. This is not the situation with bypass, for example. I have talked to a number of people that felt their bypass at least lessened their angina, for example. Though the reports post bypass were not perfect, some people I have read or talked to actually were glad they had a bypass, especially those who had the single vessel robotic, minimally invasive technique. What does this tell us about the DES stent, compared to bypass, or preventive medicine, EECP, or many other methods that many report satisfaction from. The DES stent is obviously a poorly conceived product, that does not "work" in people to improve quality of life. It is something that doctors should stop putting in people, as they were warned in September by the World College of Cardiology meeting. In europe, doctors are turning away form the DES stents significantly after this meeting. In the US the doctors are continuing to endanger and harm thousands of people each week by putting these DES stents in people.
Steve, Florida, USA, February 12, 2007

• George -- Our quick recommendation in your case is to discuss the possibility of a Plavix allergy with your interventional cardiologist, really the best person to make any adjustments in your treatment. If he/she thinks you may be having an allergic reaction to Plavix, it may be possible to switch to an earlier (although related) drug called Ticlid (ticlopidine). We're also sending you information on the "Stent Allergy Study".
Forum Editor, Angioplasty.Org, February 12, 2007

• I had a Cypher stent inserted in the proximal area of the LAD six days ago (100% blockage, supplemented by collateral growth of the RCA). Initially, I thought I was having an allergic reaction to the adhesive on the electrode pads, since the rashes seemed to be concentrated in those areas, Today, the rash has spread covering much of the upper torso, front and back. I began taking clopidogrel 75mg immediately after the catheterization (initial dose may have been higher, it was more than a couple pills), been taking a daily 325mg aspirin for years prior. The itching is fairly severe, and does not seem to respond to benadryl, either orally or topical cream. Found angioplasty.org by Google search looking for similar symptoms, and advice for relief. Not sure what your study entails, but would be interested in participating.
George C., Florida, USA, February 11, 2007

• Brenda -- can you be more specific as to what type of pain? Is it angina (chest pain?) Also where is it and when did it start? Has he had any follow-up angiograms or stress tests to determine if the stents are open?
Forum Editor, Angioplasty.Org, February 10, 2007

• Hi my husband had 4 medicated stents put in 1 yr 2 months ago.And is having so much pain from it i am so tired of doctors telling us that they have never heard of anyone having any problems with the stents and now i sit here and read and all i can do is cry for him and all of you. because no one seems to care about any of us. I don't no how long my husband can go on with the pain. he is 55 and was real active, now he can hardly move and all i hear is they can't see why is there no help for us!!!!
Brenda W., Idaho, USA, February 9, 2007

• Update of posting from October 2006 where I was asking about a driver stent. My husband was in great pain in his legs and hips, progressed to almost unable to walk, using walking cane and considering a walker. All tests re: arthritis which the Dr. insisted it was came back negative. Suddenly the condition disappeared after 6 months of excruciating pain in joints. The thinking now is that it is rare but that some people may be caused by trauma after the stent is installed. Hope this is of some comfort to others with this condition.
Nora, Canada, February 7, 2007

• Wow, Thought I was alone until I read many stories about the pain we still suffer, have suffered and the ignorance of the medical community as well as the fact that many docs simply aren't willing to listen. Follow the money. I wasn't given stent cards, info or diagnosed properly either. Still in pain looking for answers and almost every posting rings similar. two heart attacks, last one caused by clotting and six stents later few if any will own up to the fact that First Do No Harm is second to First make a buck. Your stories and experiences are important to me as you are the ones whom really understand what these stents are doing to us. Keep fighting, Keep talking and Never Give up and Don't be afraid to fire a few docs. As for me I won't take dying lying down. Thanks again for this site It can/and has made a huge difference. I stumbled on it in October of 06 after all my docs had no explanation and even less information.
Mike S., Florida, USA, February 6, 2007

• Sheila -- Can't say if such an allergy "runs in the family", but the fact that your doctor has been made aware and is treating the possibility is good. Our mission is helping communications between doctors and patients, so each can do his/her job in improving the patient's health.
Forum Editor, Angioplasty.Org, February 6, 2007

• I sure do appreciate all of your information. Can I ask one more question? my father is allergic to the dye they use for angiograms. do you think that is a family trait? (the dye allergy) my Dr. does know about this and is planning some sort of pre-treatment, steroids I think, but not sure. Thanks again, and I will be taking this with me on "A" day for my dr.
Sheila, Arizona, USA, February 5, 2007

• Sheila -- Some stents are made of cobalt-chromium, but they also have nickel. Has it been determined if you are allergic to nickel?? The possible advantage of bare metal stents (as opposed to drug-eluting) is that you don't need long term antiplatelet therapy (aspirin plus Plavix) -- 4-6 weeks supposedly suffices. Bare metal stents also have a higher restenosis rate -- especially in certain cases. But you need to discuss these issues with your interventional cardiologist -- the one who will be doing your procedure. Good luck and let us know how things proceed!
Forum Editor, Angioplasty.Org, February 5, 2007

• Hi! are there other stents available besides the stainless and the drug-eluting? I have spoken with the medical facility about these problems, they are also doing some research before they will do the angiogram. ideally, I wont need a stent. (wishful thinking!) however, it looks like I will with the comparison of my old tests to my new ones. Thanks for your reply.
Sheila, Arizona, USA, February 5, 2007

• Sheila -- Make sure that the cardiologist who is doing the angio knows these facts. An aspirin allergy and any metal allergy is something that should be known before an angio (we assume you mean angiogram, not angioplasty). If they decide to go ahead with treatment for a blockage, be aware that stents are made of surgical stainless steel, which contains nickel. They are contraindicated for patients with a known allergy to stainless steel. An allergy to aspirin might impact the decision as to whether or not to use a drug-eluting stent. Just make sure you communicate these facts clearly to the cardiologist, nurse, anyone that interacts with you. If possible, call them before you go in.
Forum Editor, Angioplasty.Org, February 5, 2007

• I was wondering how a stent would affect me if I have a metal allergy. I cannot wear jewelry that is less than 14k gold, and I cannot wear any silver or the jewelry that is plated in gold. also, I can only wear yellow gold, not the white or rose. I also have an aspirin allergy. I am scheduled for an angio possible on Friday. Thanks
Sheila, Arizona, USA, February 5, 2007

• What are some of the possible side effects of a drug eluted stent? My husband had one put in and I now worry what could happen, especially when no one ever mentioned any concerns.
Patricia S., Arkansas, USA, February 5, 2007

• Peter -- very detailed post (and to all posters, PLEASE try to keep them more concise -- if they're too long we try to edit them, but we just don't have that kind of time these days -- we're sure readers would prefer shorter posts). Anyway you've been on Plavix for over three years and (this is NOT medical advice) you're probably out of the woods vis-a-vis late stent thrombosis. But by all means do what your cardiologist recommends. Your story is a good one that emphasizes why drug-eluting stents were developed. You had bare metal stents that restenosed (re-blocked). Your drug-eluting stents seem to have stayed open (shingling and siding a house is not for the faint-hearted -- pun intended). The rash you describe could be due to many different causes -- since you were rash-free for three years post-stenting, it would be difficult to assign this as an allergy to the stent or to a drug. Drug allergies sometimes take time to manifest, but three years is a long time. Were there any changes to your meds around the time of your rash, and by meds we would include ANY over-the-counter meds or herbal supplements?
Forum Editor, Angioplasty.Org, Jan